Induction of hypersensitivity to host tissue, producing autoimmune arthritis,

Induction of hypersensitivity to host tissue refers to an abnormal immune response where the body's defense system mistakenly identifies its own cells and tissues as harmful invaders. This misguided reaction triggers inflammation and damage to the affected areas. In the case of autoimmune arthritis, the immune system specifically targets the joints, leading to chronic inflammation, pain, swelling, and eventual joint destruction. This hypersensitive response involves the activation of immune cells that release inflammatory mediators and autoantibodies, which attack the cartilage and synovial membrane lining the joints. Over time, this can result in decreased mobility and deformities. Understanding how hypersensitivity develops and contributes to autoimmune conditions like arthritis is critical for devising effective treatments that can modulate the immune system and reduce tissue damage.